Two-Stage Adaptive Dose-Finding Clinical Trial Design

Documentation for package ‘iAdapt’ version 2.0.1

dlt.prob	Calculate DLT probability corresponding to average nTTP for each dose
eff.stg1	Generates efficacy outcomes for stage 1 when using binary toxicity
eff.stg1.nTTP	Generates efficacy outcomes for stage 1 when using nTTP to measure toxicity
get.thresh	Obtain average nTTP at each dose level
LRtox	Calculates likelihood of safety for single dose
LRtox.nTTP	Calculates likelihood of safety for single dose, using nTTP
nTTP.indiv.sim	Simulate full trial (both stages) x times when using nTTP to measure toxicity
rand.prob	Calculates randomization probabilities and dose allocation for next patient
rand.stg2	Stage 2 Adaptive Randomization
rand.stg2.nTTP	Stage 2 Adaptive Randomization with nTTP to monitor toxicity
safe.dose	Identify safe/acceptable doses from stage 1 based on observed binary toxicity
safe.dose.nTTP	Identify safe/acceptable doses from stage 1 based on nTTP scores.
sim.plot	Generate plots for estimated percent allocation and response per dose.
sim.summary	Visualize simulation results (Stages 1&2)
sim.trials	Simulate full trial (both stages) x times
sim.trials.nTTP	Simulate full trial (both stages) x times when using nTTP to measure toxicity
TOX	Sample array of toxicity probabilities for 6 doses. Taken from Du et al.
tox.profile	Generates DLTs and calculates the likelihood-ratio (LR) for each dose
tox.profile.nTTP	Generate nTTPs toxicity scores and the likelihhood-ratio (LR) per dose