Package: dtpcrm
Type: Package
Title: Dose Transition Pathways for Continual Reassessment Method
Version: 0.1.3
Authors@R: c(person("Christina", "Yap", email = "yapchristina17@gmail.com",
                  role = c("aut")),
             person("Daniel", "Slade", email = "D.Slade@bham.ac.uk",
                  role = c("aut")),
             person("Kristian", "Brock", email = "k.brock@bham.ac.uk",
                  role = c("aut")),
             person("Yi", "Pan", email = "ypan1988@gmail.com",
                  role = c("aut")),
             person("Xiaoran", "Lai", email = "xiaoran.lai@icr.ac.uk",
                  role = c("cre"),
                  comment = c(ORCID = "0000-0002-7364-3993")))
Description: Provides the dose transition pathways (DTP) to project in advance
    the doses recommended by a model-based design for subsequent patients (stay,
    escalate, deescalate or stop early) using all the accumulated toxicity
    information; See Yap et al (2017) <doi:10.1158/1078-0432.CCR-17-0582>. DTP
    can be used as a design and an operational tool and can be displayed as a
    table or flow diagram. The 'dtpcrm' package also provides the modified
    continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with
    added practical considerations to allow stopping early when there is
    sufficient evidence that the lowest dose is too toxic and/or there is a
    sufficient number of patients dosed at the maximum tolerated dose.
License: GPL (>= 2)
Encoding: UTF-8
Imports: diagram, dfcrm
Suggests: knitr, rmarkdown, testthat
VignetteBuilder: knitr
RoxygenNote: 7.3.3
NeedsCompilation: no
Packaged: 2026-10-01 10:12:37 UTC; xlai
Author: Christina Yap [aut],
  Daniel Slade [aut],
  Kristian Brock [aut],
  Yi Pan [aut],
  Xiaoran Lai [cre] (ORCID: <https://orcid.org/0000-0002-7364-3993>)
Maintainer: Xiaoran Lai <xiaoran.lai@icr.ac.uk>
Repository: CRAN
Date/Publication: 2026-10-01 15:40:54 UTC
