Bayesian logistic regression model with optional
EXchangeability-NonEXchangeability parameter modelling for flexible
borrowing from historical or concurrent data-sources. The safety model
can guide dose-escalation decisions for adaptive oncology Phase I
dose-escalation trials which involve an arbitrary number of
drugs. Please refer to Neuenschwander et al. (2008)
<doi:10.1002/sim.3230> and Neuenschwander et al. (2016)
<doi:10.1080/19466315.2016.1174149> for details on the methodology.
| Version: |
0.9-0 |
| Depends: |
R (≥ 3.5.0), RBesT (≥ 1.8-0) |
| Imports: |
methods, Rcpp (≥ 0.12.0), RcppParallel (≥ 5.0.1), rstan (≥
2.32.0), rstantools (≥ 2.4.0), posterior (≥ 1.5.0), assertthat (≥ 0.2.1), checkmate, Formula, bayesplot (≥
1.4.0), ggplot2 (≥ 3.0.0), dplyr (≥ 1.1.0), tibble, tidyr (≥
1.0.0), abind, scales, rlang (≥ 0.3.0), tidyselect, utils, stats, matrixStats, brms, lifecycle, grDevices |
| LinkingTo: |
BH (≥ 1.75.0), Rcpp (≥ 0.12.0), RcppEigen (≥ 0.3.3.3.0), RcppParallel (≥ 5.0.1), rstan (≥ 2.32.0), StanHeaders (≥
2.32.0) |
| Suggests: |
rmarkdown, knitr, testthat (≥ 2.0.0), withr, mvtnorm, vdiffr, cmdstanr (≥ 0.4.0), ragg |
| Published: |
2025-03-01 |
| DOI: |
10.32614/CRAN.package.OncoBayes2 |
| Author: |
Novartis Pharma AG [cph],
Sebastian Weber [aut, cre],
Lukas A. Widmer [aut],
Andrew Bean [aut],
Trustees of Columbia University [cph] (R/stanmodels.R, configure,
configure.win) |
| Maintainer: |
Sebastian Weber <sebastian.weber at novartis.com> |
| License: |
GPL (≥ 3) |
| NeedsCompilation: |
yes |
| SystemRequirements: |
GNU make, pandoc (>= 1.12.3), pngquant, C++17 |
| Additional_repositories: |
https://mc-stan.org/r-packages/ |
| Materials: |
NEWS |
| CRAN checks: |
OncoBayes2 results |