crmPack: Object-Oriented Implementation of CRM Designs

Implements a wide range of model-based dose escalation designs, ranging from classical and modern continual reassessment methods (CRMs) based on dose-limiting toxicity endpoints to dual-endpoint designs taking into account a biomarker/efficacy outcome. The focus is on Bayesian inference, making it very easy to setup a new design with its own JAGS code. However, it is also possible to implement 3+3 designs for comparison or models with non-Bayesian estimation. The whole package is written in a modular form in the S4 class system, making it very flexible for adaptation to new models, escalation or stopping rules.

Version:	1.0.6
Depends:	R (≥ 3.0.0), ggplot2 (≥ 2.0.0), graphics
Imports:	methods, grid, gridExtra, GenSA, mvtnorm, parallel, rjags, utils, tools, MASS
Suggests:	ggmcmc, knitr, Rcpp, RcppArmadillo
Published:	2024-06-26
DOI:	10.32614/CRAN.package.crmPack
Author:	Daniel Sabanes Bove [aut, cre], Wai Yin Yeung [aut], Giuseppe Palermo [aut], Thomas Jaki [aut]
Maintainer:	Daniel Sabanes Bove <daniel.sabanes_bove at rconis.com>
BugReports:	https://github.com/openpharma/crmPack/issues
License:	GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
Copyright:	F. Hoffmann-La Roche Ltd
URL:	https://github.com/openpharma/crmPack
NeedsCompilation:	no
Citation:	crmPack citation info
Materials:	NEWS
In views:	ClinicalTrials, ExperimentalDesign
CRAN checks:	crmPack results

Documentation:

Reference manual:	crmPack.pdf
Vignettes:	Guidelines for developers and maintainer crmPack: Object-oriented implementation of CRM designs

Downloads:

Package source:	crmPack_1.0.6.tar.gz
Windows binaries:	r-devel: crmPack_1.0.6.zip, r-release: crmPack_1.0.6.zip, r-oldrel: crmPack_1.0.6.zip
macOS binaries:	r-release (arm64): crmPack_1.0.6.tgz, r-oldrel (arm64): crmPack_1.0.6.tgz, r-release (x86_64): crmPack_1.0.6.tgz, r-oldrel (x86_64): crmPack_1.0.6.tgz
Old sources:	crmPack archive

Linking:

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